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Acta Parasitologica, Vol.43, No. 1, 1998, 50-53
Philippe Gautret (1), Patrice Le Pape (2), Jean-Francois Biard (3), Didier Menard (1), Jean-Francois Verbist (3), Marjolet Michel(1) - The effects of bistramides on rodent malaria.

(1) Laboratoire de Parasitologie et de Pathologie Exotique, Faculte de Medecine, 1 rue Gaston Veil 44035 Nantes cedex 01; (2) Laboratoire de Parasitologie et d'Organisation Animale, Faculte de Pharmacie, 1 rue Gaston Veil 44035 Nantes cedex 01; (3) Groupe de Recherche "Substances Marines Activite Biologique" (SMAB), ISOMer, Faculte de Pharmacie, 1 rue Gaston Veil 44035 Nantes cedex 01; France
ABSTRACT

Bistramide D and K were extracted from a New Caledonian marine colonial ascidian Lissoclinum bistratum and tested against Plasmodium berghei and P. vinckei petteri in mice. Bistramide D was able to reduce parasitaemia by almost 50% in P. berghei infected mice, but the ID50 (>5 mg/kg) was very close to the LD50 (8 mg/kg). In the same assay, bistramide K was less active than bistramide D. The mid-term trophozoite and the old trophozoite were shown to be the stages most sensitive to bistramide D in P. vinckei petteri infected mice. Therefore, bistramides are interesting experimental tools but do not present a major interest as potential antimalarial drugs.


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