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*Corresponding author.
The host-parasite relationship of the post-infection tissue resident and migratory stages of Uncinaria stenocephala are areas, which have received very little attention to-date. In the present experiments cellular and serum antibody responses were evaluated in mice infected percutaneously with infective larvae of the nematode. Significant eosinophil infiltration was observed in the skin at the site of infection. The number of these cells increased significantly (p<0.01) and dramatically at the site of the first infection (abdomen) within 24 h of exposure to the second dose of larvae which was administered at a different site (back). A clear IgE response of mice to somatic and surface antigens of L3 was observed. There was no further increase in IgE to the somatic antigen preparations following challenge, but a significantly higher concentration of IgE reactivity to surface antigens was detected 14 days after challenge. A short-lived, IgM, IgG and IgA response to the somatic antigens was also detected.