Acta Parasitologica, Vol. 51, No. 1, 2006, 73-78 Alicia Gomez-Barrio(1)*, David Montero-Pereira(1), Juan J. Nogal-Ruiz(1), Jose A. Escario(1),
Susana Muelas-Serrano(1), Vladimir V. Kouznetsov(2), Leonor Y. Vargas Mendez(2),
Juan M. Urbina GonzAles(2) and Carmen Ochoa(3) - Antiparasitic properties of homoallylamines
and related compounds
(1)Departamento de Parasitologia, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain; (2)Laboratory of Fine Organic
Synthesis, Research Center for Biomolecules, School of Chemistry, Industrial University of Santander, A.A. 678, Bucaramanga,
Colombia; (3)Instituto de Quimica Medica (CSIC), Juan de la Cierva, 3, 28006 Madrid, Spain
*Corresponding author: agbarrio@farm.ucm.es
ABSTRACT
A study of some antiparasitic properties of several homoallylamines and related tetrahydroquinolines and quinolines, previously
described, was carried out using in vitro activity assays against the epimastigote form of Trypanosoma cruzi and against
Trichomonas vaginalis. Unspecific cytotoxicity against murine macrophages was also studied. Although the antichagasic and
trichomonacidal activities are not comparable to those of the standard drugs, nifurtimox and metronidazole, some of the compounds
exhibit an interesting specific antiparasitic activity.
KEY WORDS: Homoallylamines, tetrahydroquinolines, quinolines, antichagasic, trichomonacidal, unspecific cytotoxicity